Guanosin

A lo Guanosine bi agbedemeji Valaciclovir.
Valacyclovir jẹ oogun ajẹsara afọwọṣe guanine kan.O ti wa ni lo ninu awọn isẹgun itọju ti Herpes simplex ati Herpes zoster ikolu ni ibalopọ zqwq arun.Ọja yii jẹ iṣaju ti acyclovir.O gba ni kiakia lẹhin iṣakoso ẹnu ati ni kiakia yipada si acyclovir ninu ara.Ipa antiviral rẹ jẹ ṣiṣẹ nipasẹ acyclovir.Lẹhin ti acyclovir ti wọ inu awọn sẹẹli ti o ni arun Herpes, o dije pẹlu deoxynucleoside fun ọlọjẹ thymidine deoxynucleoside kinase tabi cell kinase, ati pe oogun naa jẹ phosphorylated sinu acyclic guanosine triphosphate ti mu ṣiṣẹ.Gẹgẹbi sobusitireti ti ẹda ọlọjẹ, acyclovir dije pẹlu deoxyguanine triphosphate fun ọlọjẹ DNA polymerase, eyiti o ṣe idiwọ iṣelọpọ DNA ọlọjẹ ati ṣafihan ipa antiviral.Iṣẹ ṣiṣe antiviral ti ọja yii ni vivo dara ju acyclovir, ati atọka itọju ti Herpes simplex virus type I ati iru II jẹ 42.91% ati 30.13% ga ju acyclovir lọ ni atele.O tun ni ipa itọju giga lori ọlọjẹ varicella zoster.