8-Bromo-7-ṣugbọn-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3
8-Bromo-7-ṣugbọn-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3
Lo:Aarin fun Linagliptin.
Lilo:Aarin fun Linagliptin
Iwọn alaṣẹ:bošewa kekeke
Ayẹwo:98-102%
Òde:Funfun si ina ofeefee lulú
Apo:25kg / ilu
Lati ṣe itupalẹ linagliptin ti o wa ati bọtini agbedemeji 8-bromo-7- (2-butynyl) -3,7-dihydro-3-methyl-1-[(4-methyl -2-quinazolinyl)methyl) -1H-purine- 2,6-dione (11) ọna iṣelọpọ, wa ipa ọna sintetiki ti o dara fun iṣelọpọ ile-iṣẹ.Ọna: akopọ awọn oriṣiriṣi awọn ipa-ọna sintetiki.Awọn abajade ati awọn ipari: Ipa ọna 2.2 ni ilana ti o rọrun ati idiyele kekere, eyiti o dara julọ fun iṣelọpọ ile-iṣẹ.
8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione jẹ agbedemeji bọtini ninu iṣelọpọ ti oogun hypoglycemic ti linagliptin.Iṣọkan ti 1 nlo methyl urea ati cyanoacetic acid bi awọn ohun elo ti o bẹrẹ, ati pe o gba awọn aati-igbesẹ mẹfa ti condensation, cyclization, nitrosation, idinku, cyclization, ati bromine pẹlu apapọ ikore ti 46.3%.Awọn ẹya ti gbogbo awọn agbedemeji jẹ timo nipasẹ 1HNMR.
Ipilẹṣẹ lọwọlọwọ ni ibatan si ọna igbaradi ti o rọrun ti linagliptin mimọ-giga.Quinazoline, agbedemeji bọtini fun igbaradi ikoko-ọkan ti linagliptin 8 bromo 7 (2 butyne 1 base) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, agbedemeji ti yapa nipasẹ sisẹ, ati lẹhinna fesi pẹlu (R) 3 aminopiperidine dihydrochloride lati gba ojutu ti o ni linagliptin ninu.Lẹhin ti ojutu ti o ni linagliptin ti ni ilọsiwaju lẹẹkansi, Deliraliptin ọja mimọ.Igbaradi ti agbedemeji bọtini ti kiikan lọwọlọwọ gba ọna ikoko kan, eyiti o rọrun lati ṣiṣẹ ati ilọsiwaju ikore.Lẹhin ti aarin bọtini ti yapa, o ti ṣe pẹlu (R) 3 aminopiperidine dihydrochloride, nitorinaa Gbigba linagliptin mimọ-giga tun pade iṣelọpọ ati awọn ibeere ikede ti awọn ile-iṣẹ elegbogi si iwọn ti o tobi julọ.
JIN DUN Medical niIjẹrisi ISO ati pade awọn iṣedede iṣelọpọ GMP, oojọ ti abele ati ajeji oogun kolaginni amoye pẹlu ọlọrọ iriri lati dari R&D ile-iṣẹ.
TECHNOL OGY anfani
● Giga titẹ agbara ti o ni itọsi hydrogenation.Iṣeduro Hydrogenolysis Ipa giga.Idahun Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
● Iṣe atunṣe
● Ipinnu Chiral
●Hekki, Suzuki,Negishi,Sonogashira .Gignard lenu
Awọn ohun elo
Lab wa ni orisirisi awọn ohun elo idanwo ati awọn ohun elo idanwo, gẹgẹbi: NMR (Bruker 400M), HPLC, Chiral-HPLC, LC-MS, LC-MS/MS (API 4000) Makirowefu Synthesizer, Parallel Synthesizer, Iyatọ Ṣiṣayẹwo Calorimeter (DSC), Maikirosikopu Electron...
R&D Egbe
Jindun Medical ni ẹgbẹ kan ti oṣiṣẹ R&D alamọdaju, o si gba ọpọlọpọ awọn amoye iṣelọpọ oogun ti ile ati ajeji lati ṣe itọsọna R&D, ṣiṣe iṣelọpọ wa ni deede ati daradara.
A ti ṣe iranlọwọ fun ọpọlọpọ awọn ile-iṣẹ elegbogi inu ile, biiHansoh, Hengrui ati HEC Pharm.Nibi a yoo ṣe afihan apakan ninu wọn.
Ọran Isọdi Ọkan:
Cas No.: 110351-94-5
Isọdi Isọdi Meji:
Cas No.: 144848-24-8
Ọran Isọdọtun Mẹta:
Cas No.: 200636-54-0
1.Ṣe akanṣe Awọn agbedemeji Tuntun tabi APIs.Kanna gẹgẹbi pinpin ọran loke, awọn alabara ni awọn ibeere fun Awọn agbedemeji kan pato tabi awọn API, ati pe wọn ko le rii awọn ọja ti o nilo ni ọja, lẹhinna a le ṣe iranlọwọ lati Ṣe akanṣe.
2.Imudara ilana fun Awọn ọja atijọ.Ẹgbẹ wa yoo ṣe iranlọwọ lati mu ki o mu iru iṣelọpọ pọ si ti ipa ọna iṣe rẹ jẹ arugbo, idiyele iṣelọpọ ga, ati ṣiṣe jẹ kekere.A le pese iwe kikun fun gbigbe imọ-ẹrọ ati ilọsiwaju ilana, iranlọwọ alabara fun iṣelọpọ ti o munadoko diẹ sii.
Lati awọn ibi-afẹde oogun si awọn IND, Iṣoogun JIN DUN pese fun ọawọn solusan R&D ti ara ẹni iduro-ọkan.
Iṣoogun JIN DUN tẹnumọ lori ṣiṣẹda ẹgbẹ kan pẹlu awọn ala, ṣiṣe awọn ọja ti o ni ọlá, titọ, lile, ati lilọ gbogbo jade lati jẹ alabaṣepọ ti o gbẹkẹle ati ọrẹ awọn alabara!
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